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Immune Design and Medicago Announce License Agreement and Collaboration to Develop Novel Adjuvanted Pandemic Influenza Vaccines

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SEATTLE and QUEBEC CITY, June 27, 2013 /CNW/ - Immune Design, a leader in the field of therapeutic vaccines for cancer, infectious diseases and allergy, and Medicago Inc. (TSX: MDG; OTCQX: MDCGF), a biopharmaceutical company focused on developing highly effective and competitive vaccines based on proprietary manufacturing technologies and Virus-Like Particles (VLPs), today announced that they have entered a license agreement providing Medicago the use and commercialization of Immune Design's proprietary synthetic Toll-like Receptor 4 agonist, Glucopyranosyl Lipid A (GLA). Medicago has the option to use Immune Design's molecular adjuvant in its vaccines for various pandemic influenza strains.

Under the terms of the agreement, Immune Design has granted Medicago a worldwide, nonexclusive license to research, develop, and commercialize GLA as a component of its VLP-based vaccines in the field of pandemic influenza. Other terms were not disclosed.

"We are pleased to enter into this collaboration with Medicago and allow for our proprietary adjuvant to be utilized in their vaccine candidates for pandemic influenza," states Carlos Paya, MD, PhD, Immune Design's President and Chief Executive Officer. "Medicago has demonstrated a track record to date, of rapid and successful vaccine candidates design and production which have them at the forefront of next generation vaccine development."

"The established clinical safety and immunogenicity profile of Immune Design's synthetic TLR4 agonist, GLA, make it an ideal adjuvant for our VLP-based influenza vaccine candidates," said Andy Sheldon, Medicago's President and Chief Executive Officer.  "We will further investigate the use of both formulated GLA and alum in our Phase II H5N1 trial which was recently initiated with results expected during the summer of 2013."

Medicago's first vaccine candidate in the field, which targets the H5N1 influenza strain, completed a successful U.S. Phase I study which was conducted with the Infectious Disease Research Institute (IDRI), earlier this year. In that study, all three configurations of adjuvant and route of administration (I.D., Alum, and GLA-AF) for 20ug of the H5N1 vaccine candidate induced a solid immune response against the H5N1 viral strain that exceeded the CHMP immunogenicity criteria for licensure of influenza vaccines. Medicago recently initiated a Phase II study of its H5N1 VLP in combination with both the GLA and alum adjuvants with results expected in the summer of 2013.

Medicago also recently announced the production of a H7N9 VLP vaccine candidate which includes formulated GLA or alum, making Medicago the first company to successfully produce a VLP vaccine candidate against the emerging strain. Medicago and Immune Design are collaborating to conduct preclinical studies of the H7N9 VLP-GLA combination.

About Medicago
Medicago is a clinical-stage biopharmaceutical company developing novel vaccines and therapeutic proteins to address a broad range of infectious diseases worldwide. The Company is committed to providing highly effective and competitive vaccines and therapeutic proteins based on its proprietary VLP and manufacturing technologies. Medicago is a worldwide leader in the development of VLP vaccines using a transient expression system which produces recombinant vaccine antigens in plants. This technology has potential to offer more potent vaccines with speed and cost advantages over competitive technologies, enabling the development of a vaccine for testing in approximately one month after the identification and reception of genetic sequences from a pandemic strain. This production time frame has the potential to allow vaccination of the population before the first wave of a pandemic, and supply large volumes of vaccine antigens to the world market. Medicago also intends to expand development into other areas such as biosimilars and biodefense products where the benefits of our technologies can make a significant difference. Additional information about Medicago is available at www.medicago.com.

About Immune Design:
Immune Design is a privately held, clinical stage biotechnology company based in Seattle, WA. Immune Design brings together some of the world's leaders in the field of molecular immunology to develop next generation, therapeutic, and preventative vaccines for malignant, infectious and allergic diseases. The company employs leading edge technologies which target dendritic cells for more precise activation of the immune response. These include a novel lentiviral vector engineered to deliver antigen-encoding nucleic acids directly to dendritic cells in vivo and a TLR-4 agonist that activates dendritic cells by up-regulating key molecules for efficient antigen presentation, and produces cytokines of the Th1 type to enhance the immune response.  The TLR-4 agonist is licensed from the Infectious Disease Research Institute, or IDRI, for worldwide exclusive rights in a number of indications, including influenza.  For more information, go to www.immunedesign.com.

Forward Looking Statements

This news release includes certain forward-looking statements or forward-looking information for the purposes of applicable securities laws and such statements and information are based upon current expectations, which involve risks and uncertainties associated with Medicago's business and the environment in which the business operates. Any statements contained herein that are not statements of historical facts may be deemed to be forward-looking, including those identified by the expressions "anticipate", "believe", "plan", "estimate", "expect", "intend", and similar expressions to the extent they relate to Medicago or its management. The forward-looking statements are not historical facts, but reflect Medicago's current expectations regarding future results or events. These forward-looking statements are subject to a number of risks and uncertainties that could cause actual results or events to differ materially from current expectations, including the matters discussed under "Risk Factors and Uncertainties" in Medicago's Annual Information Form filed on March 28, 2013, with the regulatory authorities. Medicago assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those reflected in the forward-looking statements.

Contact: 

Medicago Inc. 
Andy Sheldon 
President and CEO 
(418) 658-9393

Medicago Inc. 
Christina Cameron
Investor Relations 
(418) 658-9393 ext.156

Immune Design  
Paul Rickey 
VP, Finance and Administrations 
media@immunedesign.com 
(206) 682-0645

Immune Design
Julie Rathbun
Rathbun Communications
Julie@rathbuncomm.com
(206) 769-9219


Medicago announces agreement to be acquired by Mitsubishi Tanabe Pharma in a transaction valued at $357M

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QUÉBEC CITY, July 12, 2013 /CNW/ - Medicago Inc. (TSX: MDG; OTCQX: MDCGF), a biopharmaceutical company focused on developing highly effective and competitive vaccines based on proprietary manufacturing technologies and Virus-Like Particles (VLPs), announced today that it has entered into a definitive arrangement agreement with Mitsubishi Tanabe Pharma Corporation ("Mitsubishi Tanabe Pharma" or "MTPC") whereby MTPC will acquire all of the issued and outstanding common shares ("Shares") of Medicago, other than the Shares currently held byPhilip Morris Investments B.V. ("PMI") an affiliate of Philip Morris International Inc. and MTPC, for $1.16 in cash per Share (the "Purchase Price").  Upon completion of the transaction, Medicago will be jointly owned by MTPC (60%) and PMI (40%).

The Purchase Price represents a premium of approximately 22.1% to the closing price of $0.95 per Share on the TSX on July 11, 2013 and a premium of approximately 46.8% and 61.1% over the 30-day and 90-day volume weighted average prices of $0.79 and $0.72 per Share on the TSX, respectively, up to and including July 11, 2013.  The transaction represents a total enterprise value of approximately $357 million, including the assumption of existing indebtedness, for 100% of Medicago.

The transaction has been approved unanimously by the Board of Directors of Medicago following the unanimous recommendation of a Special Committee of Independent Directors. The Board of Directors of Medicago also unanimously recommends that shareholders vote in favour of the transaction at the special meeting of shareholders to be called to approve the transaction. PMI, Medicago's principal shareholder, which currently holds 38.5% of all issued and outstanding Shares of Medicago, has agreed to irrevocably support and vote its Shares in favour of the transaction until April 12, 2014. In addition, all directors and certain officers of Medicago holding approximately 1.6% of the issued and outstanding Shares have also entered into agreements pursuant to which they have agreed to vote their Shares in favour of the transaction.

"Mitsubishi Tanabe Pharma, a top 30 global pharmaceutical company, has been a solid and committed partner with the ability to drive Medicago's future growth and success in the development of our best-in-class rapid plant-based vaccines," said Andy Sheldon, President and CEO of Medicago. "Mitsubishi Tanabe Pharma's capabilities in biopharmaceutical research, development, and commercialization along with its financial stability offer us the ideal opportunity to realize the full potential of our platform. These resources provide us the ability to foster the development of innovative vaccines with the financial stability to expand our Quebec, Canadian, U.S. and global operations."

"Building on our existing collaboration, we look forward to working with the management and employees of Medicago to further develop the business and advance their promising work," said Michihiro Tsuchiya, Representative Director of Mitsubishi Tanabe Pharma Corporation.  "We are proud to invest in developing novel vaccines in Québec City and North Carolina as part of our global operations."

Fairness Opinions and Formal Valuation

TD Securities Inc. ("TD Securities"), as financial advisor to Medicago, and Desjardins Capital Markets ("Desjardins"), as independent valuator to the Special Committee, have each provided an opinion to the Special Committee and Board of Directors of Medicago that, subject to the assumptions, qualifications and limitations provided therein, the consideration to be received by the shareholders (other than MTPC and PMI) under the arrangement is fair, from a financial point of view, to such shareholders. Desjardins has also provided the Special Committee with a formal valuation completed under the supervision of the Special Committee, as contemplated by Regulation 61-101 Protection of Minority Security Holders in Special Transactions ("Regulation 61-101"), and which concludes that, subject to the assumptions, qualifications and limitations therein, the fair market value of the Shares is between $1.05 and $1.35 per Share.

Transaction Details

The completion of the transaction is subject to court approval pursuant to the Business Corporations Act (Québec) and the approval of Medicago's shareholders. The transaction is subject to Regulation 61-101 and the implementation of the arrangement will be subject to the approval of 66 2/3% of the votes cast by shareholders present in person or by proxy at the special meeting of shareholders of Medicago and by holders of more than 50% of the votes cast by Medicago's minority shareholders being all shareholders excluding MTPC, PMI and any of their respective affiliates. The Company intends to mail a management information circular in the upcoming weeks to its shareholders for a meeting expected to be held before August 30, 2013. The transaction is also subject to customary closing conditions, including receipt of all regulatory approvals, and is expected to close later this calendar year. The transaction is not subject to any financing condition.

The arrangement agreement provides for, among other things, a non-solicitation covenant on the part of Medicago subject to customary fiduciary out provisions. The arrangement agreement also provides MTPC with a "right to match" and requires Medicago to pay a termination fee in the amount of $9.25 million under certain circumstances.  MTPC has agreed to pay Medicago a termination fee of $9.25 million if the transaction is not completed as a result of a breach of representations or covenants by MTPC. MTPC has also agreed to reimburse Medicago's expenses related to the transaction, up to an amount of $1,500,000, in the event the transaction does not close as a result of certain regulatory approvals not being obtained.

Upon closing of the transaction, holders of warrants and stock options of Medicago will receive a cash payment equal to the difference between$1.16 and the exercise price of such warrant or stock options.

MTPC has also agreed, subject to the necessary regulatory approvals being secured, to make available to Medicago a non-interest bearing loan in a principal amount not to exceed $13.5 million in three instalments for the purpose of providing Medicago with adequate cash liquidity until closing of the transaction should closing not have occurred by September 15, 2013.  In the event the arrangement agreement is terminated and the transaction does not close, the loan will become due and payable, and Medicago will satisfy its obligations to repay the loan through the issuance of Shares to MTPC at a price of $0.82 per Share.

Further details regarding the terms of the transaction are set-out in an Arrangement Agreement which will be available under the profile of Medicago at www.sedar.com.

Advisors

TD Securities is financial advisor to Medicago in connection with the transaction and Desjardins Capital Markets acted as independent valuator to the Special Committee of Medicago. McCarthy Tétrault LLP is Medicago's legal counsel. MTPC's financial advisor is Goldman Sachs and its legal counsel are Stikeman Elliott LLP and Ropes & Gray LLP.

About Medicago

Medicago is a clinical-stage biopharmaceutical company developing novel vaccines and therapeutic proteins to address a broad range of infectious diseases worldwide. The Company is committed to providing highly effective and competitive vaccines and therapeutic proteins based on its proprietary VLP and manufacturing technologies. Medicago is a worldwide leader in the development of VLP vaccines using a transient expression system which produces recombinant vaccine antigens in plants. This technology has potential to offer more potent vaccines with speed and cost advantages over competitive technologies, enabling the development of a vaccine for testing in approximately one month after the identification and reception of genetic sequences from a pandemic strain. This production time frame has the potential to allow vaccination of the population before the first wave of a pandemic, and supply large volumes of vaccine antigens to the world market. Medicago also intends to expand development into other areas such as biosimilars and biodefense products where the benefits of our technologies can make a significant difference. Additional information about Medicago is available at www.medicago.com.

About Mitsubishi Tanabe Pharma

Mitsubishi Tanabe Pharma is a research-driven pharmaceutical company based in Japan, specializing in research, development and marketing of globally competitive pharmaceutical products focused on the field of autoimmune disease, diabetes and kidney disease, and CNS disease.  Mitsubishi Tanabe Pharma contributes to the healthier lives of people around the world through the creation of pharmaceuticals that respond to unmet medical needs.
Additional information about MTPC is available at http://www.mt-pharma.co.jp/e

Forward Looking Statements
This news release includes certain forward-looking statements or forward-looking information for the purposes of applicable securities laws and such statements and information are based upon current expectations, which involve risks and uncertainties associated with Medicago's business and the environment in which the business operates. Any statements contained herein that are not statements of historical facts may be deemed to be forward-looking, including those identified by the expressions "anticipate", "believe", "plan", "estimate", "expect", "intend", and similar expressions to the extent they relate to Medicago or its management. The forward-looking statements are not historical facts, but reflect Medicago's current expectations regarding future results or events. These forward-looking statements are subject to a number of risks and uncertainties that could cause actual results or events to differ materially from current expectations, including the matters discussed under "Risk Factors and Uncertainties" in Medicago's Annual Information Form filed on March 28, 2013, with the regulatory authorities. Medicago assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those reflected in the forward-looking statements.

Medicago Inc.  
Andy Sheldon
President and CEO
(418) 658-9393

Medicago Inc.
Christina Cameron
Investor Relations
cameronc@medicago.com
(418) 658-9393 ext.156

For inquiries regarding Mitsubishi Tanabe Pharma Corporation:
Josiane Hébert
H K Stratégies
josiane.hebert@hkstrategies.ca
(418) 569-1490

Medicago announces special meeting of shareholders to be held on August 29, 2013 to approve the Transaction with Mitsubishi Tanabe Pharma

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QUEBEC CITY, July 31, 2013 /CNW/ - Medicago Inc. (TSX: MDG; OTCQX: MDCGF) ("Medicago"), a biopharmaceutical company focused on developing highly effective and competitive vaccines based on proprietary manufacturing technologies and Virus-Like Particles (VLPs), announced today that it has obtained on July 25, 2013 an interim order from the Superior Court of Québec (the "Interim Order") authorizing, among other things, Medicago to hold a special meeting (the "Meeting") of shareholders of Medicago (the "Shareholders") relating to the previously announced plan of arrangement involvingMitsubishi Tanabe Pharma Corporation ("MTPC").

The Meeting to consider the Arrangement Resolution will be held at McCarthy Tétrault LLP's office located at 1000 De La Gauchetière Street West, Suite 2500, Montréal, Québec, H3B 0A2, on August 29, 2013 at11:00 a.m. (EDT). The record date for voting at the Meeting is July 30, 2013.

At the Meeting, Shareholders will be asked to consider and, if deemed advisable, to approve a special resolution (the "Arrangement Resolution"), the full text of which is set forth in Appendix A to the management information circular dated July 31, 2013 (the "Circular"), to approve a statutory arrangement (the "Arrangement") under Chapter XVI - Division II of the Business Corporations Act (Québec) involving the Corporation, MTPC and 9284-9686 Québec inc. (the "Purchaser"), a wholly-owned subsidiary of MTPC, whereby, among other things, the Purchaser will acquire all of the common shares of Medicago not held byMTPC and Philip Morris Investments B.V. ("PMI") for a cash consideration of $1.16 per common share, all as more particularly described in the Circular.

The Circular and accompanying materials are being mailed to the Shareholders and will be available on Medicago's website at www.medicago.com or SEDAR at www.sedar.com. Shareholders are urged to carefully review the Circular and accompanying materials as they contain important information regarding the Arrangement and its consequences to Shareholders.

The Arrangement is subject to the approval of 66 2/3% of the votes cast by Shareholders and of more than 50% of the votes cast by Medicago's minority Shareholders being all shareholders excluding MTPC, PMI and any of their respective affiliates; in each case present in person or represented by proxy at the Meeting. The Arrangement is also subject to customary closing conditions, including receipt of all regulatory approvals. Assuming that the Arrangement Resolution is approved at the Meeting and that all regulatory approvals are timely obtained, Medicago anticipates returning to the Superior Court of Québec on or around September 4, 2013 to seek a final order to implement the Arrangement on or around mid-September 2013.

The Board of Directors of Medicago unanimously recommends that Shareholders vote in favour of the Arrangement.

Your vote is important regardless of the number of Common Shares you own. Shareholders who have any questions regarding the Arrangement or require assistance with voting may contact Medicago's proxy solicitation agent, Laurel Hill Advisory Group at 1-877-452-7184 toll free or by email at assistance@laurelhill.com.

About Medicago
Medicago is a clinical-stage biopharmaceutical company developing novel vaccines and therapeutic proteins to address a broad range of infectious diseases worldwide. Medicago is committed to providing highly effective and competitive vaccines and therapeutic proteins based on its proprietary VLP and manufacturing technologies. Medicago is a worldwide leader in the development of VLP vaccines using a transient expression system which produces recombinant vaccine antigens in plants. This technology has potential to offer more potent vaccines with speed and cost advantages over competitive technologies, enabling the development of a vaccine for testing in approximately one month after the identification and reception of genetic sequences from a pandemic strain. This production time frame has the potential to allow vaccination of the population before the first wave of a pandemic, and supply large volumes of vaccine antigens to the world market. Medicago also intends to expand development into other areas such as biosimilars and biodefense products where the benefits of our technologies can make a significant difference. Additional information about Medicago is available at www.medicago.com.

About Mitsubishi Tanabe Pharma
Mitsubishi Tanabe Pharma is a research-driven pharmaceutical company based in Japan, specializing in research, development and marketing of globally competitive pharmaceutical products focused on the field of autoimmune disease, diabetes and kidney disease, and CNS disease.Mitsubishi Tanabe Pharma contributes to the healthier lives of people around the world through the creation of pharmaceuticals that respond to unmet medical needs. Additional information about MTPC is available at http://www.mt-pharma.co.jp/e.

Forward Looking Statements
This news release includes certain forward-looking statements or forward-looking information for the purposes of applicable securities laws and such statements and information are based upon current expectations, which involve risks and uncertainties associated with Medicago's business and the environment in which the business operates. Any statements contained herein that are not statements of historical facts may be deemed to be forward-looking, including those identified by the expressions "anticipate", "believe", "plan", "estimate", "expect", "intend", and similar expressions to the extent they relate to Medicago or its management. The forward-looking statements are not historical facts, but reflect Medicago's current expectations regarding future results or events. These forward-looking statements are subject to a number of risks and uncertainties that could cause actual results or events to differ materially from current expectations, including the matters discussed under "Risk Factors and Uncertainties" in Medicago's Annual Information Form filed on March 28, 2013, with the regulatory authorities. Medicago assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those reflected in the forward-looking statements.


SOURCE Medicago Inc.

Medicago Inc.        
Andy Sheldon
President and CEO
(418) 658-9393

Medicago Inc.
Christina Cameron
Investor Relations
(418) 658-9393 ext.156

Medicago Announces 2013 Second Quarter Financial Results

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QUEBEC CITY, Aug. 9, 2013 /CNW/ - Medicago Inc. (TSX: MDG), a biopharmaceutical company focused on developing highly effective and competitive vaccines based on proprietary manufacturing technologies and Virus-Like Particles (VLPs), today announced its operational and financial results for the second quarter ended June 30, 2013. The Company's financial statements and management report are available at www.sedar.com and at www.medicago.com.

Financial Results

For the three and six-month period ended June 30, 2013, the Company had revenues of $918,000 and $1,337,000, generated from the Master Research Collaboration Agreement with Mitsubishi Tanabe Pharma Corporation ("MTPC") for the development of a first product, a Rotavirus Like Particle (RLP) vaccine target; a joint research agreement with TRIA Bioscience Corporation as part of the license agreement signed by Medicago with Immune Design under which Immune Design has granted Medicago a worldwide, non-exclusive licence to research, develop and commercialize GLA as a component of its VLP-based vaccines in the field of pandemic influenza, and the successful completion of Medicago's research collaboration agreement with a top 10 global pharmaceutical Corporation.

Net loss for the three and six-month period ended June 30, 2013, was$9,073,000 or $0.04 per basic and diluted share and $17,789,000 or$0.07 per basic and diluted share, compared to a net loss of $8,099,000 or $0.04 per basic and diluted share and $17,087,000 or $0.07 per basic and diluted share for the three and six-month periods ended June 30, 2012.

Cash and short-term investments were $8.9 million as at June 30, 2013, a decrease of $2.4 million from December 31, 2012.

As at August 9, 2013, there were 263,229,248 common shares issued and outstanding, 12,345,714 stock options outstanding as well as 7,163,523 warrants outstanding as at August 9, 2013 are in the aggregate of 282,738,486.

Medicago announces agreement to be acquired by Mitsubishi Tanabe Pharma Corporation

On July 12, 2013, Medicago announced that it has entered into a definitive arrangement agreement with Mitsubishi Tanabe Pharma Corporation ("Mitsubishi Tanabe Pharma" or "MTPC") whereby MTPC will acquire all of the issued and outstanding common shares ("Shares") of Medicago, other than the Shares currently held by Philip Morris Investments B.V. ("PMI") an affiliate of Philip Morris International Inc. and MTPC, for $1.16 in cash per Share (the "Purchase Price").  Upon completion of the transaction, Medicago will be jointly owned by MTPC (60%) and PMI (40%). The transaction represents a total enterprise value of approximately $357 million, including the assumption of existing indebtedness, for 100% of Medicago.

The completion of the transaction is subject to court approval pursuant to the Business Corporations Act (Québec) and the approval of Medicago's shareholders. The transaction is subject to Regulation 61-101 and the implementation of the arrangement will be subject to the approval of 66 2/3% of the votes cast by shareholders present in person or by proxy at the special meeting of shareholders of Medicago and by holders of more than 50% of the votes cast by Medicago's minority shareholders being all shareholders excluding MTPC, PMI and any of their respective affiliates. The Board of Directors of Medicago unanimously recommends that Shareholders vote in favour of the Arrangement.

The Company has mailed a management information circular to its shareholders, a copy of which can be found on Medicago's website at www.medicago.com or at www.sedar.com, for special shareholders' meeting to be held on  August 29, 2013. The transaction is also subject to customary closing conditions, including receipt of all regulatory approvals, and is expected to close bymid-September 2013. Shareholders who have any questions regarding the Arrangement or require assistance with voting may contact Medicago's proxy solicitation agent, Laurel Hill Advisory Group at 1-877-452-7184 toll free or by email at assistance@laurelhill.com.

Highlights

During the second quarter of 2013:

  • Announced positive phase I clinical results for its H5N1 vaccine in a trial run by IDRI. The vaccine was found to be safe and well-tolerated and induced a solid immune response exceeding the three CHMP (Committee for Medicinal Products for Human Use) immunogenicity criteria for licensure of influenza vaccines. The vaccine was tested in three different configurations: using IDRI's Glucopyranosyl Lipid A ("GLA") formulated adjuvant, given both intramuscularly and intradermally, and using alum intramuscularly. All three configurations exceeded the CHMP criteria.
  • Raised $3.5 million through a private placement of 6.25 million common shares.
  • Successfully produced a VLP vaccine candidate for the H7N9 virus responsible for recent influenza outbreak in China and first in the world to report positive interim preclinical results
  • Produced a plant-based Rotavirus VLP vaccine candidate comprising all four structural antigens of rotavirus (VP2, VP4, VP6 and VP7) using Medicago's plant-based manufacturing platform.
  • Was granted a patent for Influenza Virus-Like Particles in Plants
  • Received authorization from Health Canada and commenced Phase II clinical trial for an H5N1 vaccine

Outlook for the remainder of 2013

  • Closing of the transaction with MTPC, following the approval by the shareholders and receipt of all regulatory approvals, is expected to occur by mid-September 2013
  • Interim data from a Phase II H5N1 clinical trial expected in the second half of this year
  • Initiation of a US Phase II clinical trial for a quadrivalent seasonal influenza vaccine with interim data expected in the second half of this year.

About Medicago

Medicago is a clinical-stage biopharmaceutical company developing novel vaccines and therapeutic proteins to address a broad range of infectious diseases worldwide. The Company is committed to providing highly effective and competitive vaccines and therapeutic proteins based on its proprietary VLP and manufacturing technologies. Medicago is a worldwide leader in the development of VLP vaccines using a transient expression system which produces recombinant vaccine antigens in plants. This technology has potential to offer more potent vaccines with speed and cost advantages over competitive technologies, enabling the development of a vaccine for testing in approximately one month after the identification and reception of genetic sequences from a pandemic strain. This production time frame has the potential to allow vaccination of the population before the first wave of a pandemic, and supply large volumes of vaccine antigens to the world market. Medicago also intends to expand development into other areas such as biosimilars and biodefense products where the benefits of our technologies can make a significant difference. Additional information about Medicago is available at www.medicago.com.

Forward Looking Statements

This news release includes certain forward-looking statements that are based upon current expectations, which involve risks and uncertainties associated with Medicago's business and the environment in which the business operates. Any statements contained herein that are not statements of historical facts may be deemed to be forward-looking, including those identified by the expressions "anticipate", "believe", "plan", "estimate", "expect", "intend", and similar expressions to the extent they relate to Medicago or its management. The forward-looking statements are not historical facts, but reflect Medicago's current expectations regarding future results or events. These forward-looking statements are subject to a number of risks and uncertainties that could cause actual results or events to differ materially from current expectations, including the matters discussed under "Risk Factors and Uncertainties" in Medicago's Annual Information Form filed on March 28, 2013, with the regulatory authorities. Medicago assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those reflected in the forward-looking statements.

SOURCE Medicago Inc.

Medicago Inc.
Andy Sheldon
President and CEO
(418) 658-9393

Medicago Inc. 
Christina Cameron
Investor Relations
(418) 658-9393 ext.156
cameronc@medicago.com

Medicago Inc. announces leading independent proxy firms recommend voting in favour of the arrangement with Mitsubishi Tanabe Pharma

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QUEBEC CITY, Aug. 19, 2013 /CNW/ - Medicago Inc. (TSX: MDG; OTCQX: MDCGF) ("Medicago"), a biopharmaceutical company focused on developing highly effective and competitive vaccines based on proprietary manufacturing technologies and Virus-Like Particles (VLPs), announced today thatInstitutional Shareholder Services, Inc. ("ISS") and Glass, Lewis & Co., LLC ("Glass Lewis"), two leading independent proxy firms have both recommended that Medicago shareholders vote FOR the proposed acquisition by 9284-9686 Québec Inc. (the "Purchaser"), a wholly owned subsidiary of Mitsubishi Tanabe Pharma Corporation ("MTPC"), of all common shares of Medicago not held by MTPC and Philip Morris Investments B.V. ("PMI") for a cash consideration of $1.16 per common share, pursuant to the terms of a plan of arrangement involving Medicago, MTPC, and the Purchaser (the "Arrangement").

ISS and Glass Lewis also both recommended, should the Arrangement not be completed, the issuance of up to 16,463,415 common shares of Medicago at a price of $0.82 per common share in order for Medicago to repay interim funding to be made available to it by MTPC in certain circumstances (the "Funding Arrangement").

ISS summarized its recommendation FOR the Arrangement as follows: "A vote FOR is warranted based on a review of the terms of the transaction and, in particular, the adequate premium to minority shareholders, the favourable market reactions and no significantly noted governance concerns."

Glass Lewis summarized its recommendation FOR the Arrangement as follows: "In light of the company's small size, early stage and need for additional liquidity and capital to continue its operations beyond the next six months, and the risks of Medicago continuing on a stand-alone basis, we believe the proposed all-cash buyout is the best alternative for unaffiliated shareholders at this time. In our opinion, the purchase price represents a fair and acceptable value at which shareholders can exit their investment in the company at a premium and immediately realize such value. Based on these factors, along with the unanimous support of the board, we believe the proposed acquisition is in the best interests of shareholders. Accordingly, we recommend that shareholders vote FOR this proposal."

The meeting of the shareholders of Medicago (the "Meeting") to consider the proposed Arrangement will be held at McCarthy Tétrault LLP's office located at 1000 de La Gauchetière Street West, Suite 2500, Montréal, Québec, H3B 0A2, on August 29, 2013 at11:00 a.m. (EDT). The record date for voting at the Meeting is July 30, 2013.

The Board of Directors of Medicago unanimously recommends that shareholders of Medicago vote in favour of the Arrangement and in favour of the Funding Arrangement.

Your vote is important regardless of the number of common shares of Medicago you own. Shareholders who have any questions regarding the Arrangement or require assistance with voting may contact Medicago's proxy solicitation agent, Laurel Hill Advisory Group at 1-877-452-7184 toll free or by email at assistance@laurelhill.com.

Shareholders are urged to carefully review the management information circular of Medicago dated July 31, 2013 and accompanying materials as they contain important information regarding the Arrangement and its consequences to shareholders of Medicago.

The Arrangement is subject to the approval of 66 2/3% of the votes cast by all shareholders of Medicago and of more than 50% of the votes cast by Medicago's minority shareholders being all shareholders excluding MTPC, PMI and any of their respective affiliates; in each case present in person or represented by proxy at the Meeting. The Arrangement is also subject to customary closing conditions, including receipt of all regulatory approvals. Assuming that the Arrangement is approved at the Meeting and that all regulatory approvals are timely obtained, Medicago anticipates returning to the Superior Court of Québec on or around September 4, 2013 to seek a final order to implement the Arrangement around mid-September 2013.

How to Vote
Due to essence of time, Shareholders are urged to vote today using the methods below.

Registered Shareholders
Shareholders who have physical certificates representing Medicago shares may vote by telephone or via the Internet. To vote by telephone call 1-866-732-8683 from a touch tone phone. When prompted, enter your Control Number listed on the proxy and follow the voting instructions. To vote via the Internet, go to www.investorvote.com and enter your Control Number listed on the proxy and follow the voting instructions on the screen. If you vote by telephone or via the Internet, do not complete or return the form of proxy.

Non-Registered Shareholders
Shareholders who hold their shares through a broker or other intermediary may vote via the internet at www.proxyvote.com or following the other instructions found on the voting instruction form.

Shareholder Questions
Shareholders who have questions or need any additional information should contact their professional advisors or you may contact Laurel Hill Advisory Group, Medicago's proxy solicitation agent, toll-free at 1-877-452-7184 (416-304-0211 collect) or by email at assistance@laurelhill.com.

About ISS
ISS is Canada's leading independent proxy advisory firm and the leading authority on proxy voting and corporate governance issues in Canada with over 1,700 clients. ISS has been providing advisory and voting services to leading pension funds, investment managers, mutual funds and other institutional shareholders since 1987.

About Glass, Lewis & Co.
Founded in 2003, Glass, Lewis & Co. is a leading U.S., independent, governance analysis and proxy voting firm, serving institutional investors globally that collectively manage more than US$15 trillion in assets.

About Medicago
Medicago is a clinical-stage biopharmaceutical company developing novel vaccines and therapeutic proteins to address a broad range of infectious diseases worldwide. Medicago is committed to providing highly effective and competitive vaccines and therapeutic proteins based on its proprietary VLP and manufacturing technologies. Medicago is a worldwide leader in the development of VLP vaccines using a transient expression system which produces recombinant vaccine antigens in plants. This technology has potential to offer more potent vaccines with speed and cost advantages over competitive technologies, enabling the development of a vaccine for testing in approximately one month after the identification and reception of genetic sequences from a pandemic strain. This production time frame has the potential to allow vaccination of the population before the first wave of a pandemic, and supply large volumes of vaccine antigens to the world market. Medicago also intends to expand development into other areas such as biosimilars and biodefense products where the benefits of our technologies can make a significant difference. Additional information about Medicago is available at www.medicago.com.

About Mitsubishi Tanabe Pharma
Mitsubishi Tanabe Pharma is a research-driven pharmaceutical company based in Japan, specializing in research, development and marketing of globally competitive pharmaceutical products focused on the field of autoimmune disease, diabetes and kidney disease, and CNS disease.Mitsubishi Tanabe Pharma contributes to the healthier lives of people around the world through the creation of pharmaceuticals that respond to unmet medical needs. Additional information about MTPC is available at http://www.mt-pharma.co.jp/e.

Forward Looking Statements
This news release includes certain forward-looking statements or forward-looking information for the purposes of applicable securities laws and such statements and information are based upon current expectations, which involve risks and uncertainties associated with Medicago's business and the environment in which the business operates. Any statements contained herein that are not statements of historical facts may be deemed to be forward-looking, including those identified by the expressions "anticipate", "believe", "plan", "estimate", "expect", "intend", and similar expressions to the extent they relate to Medicago or its management. The forward-looking statements are not historical facts, but reflect Medicago's current expectations regarding future results or events. These forward-looking statements are subject to a number of risks and uncertainties that could cause actual results or events to differ materially from current expectations, including the matters discussed under "Risk Factors and Uncertainties" in Medicago's Annual Information Form filed on March 28, 2013, with the regulatory authorities. Medicago assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those reflected in the forward-looking statements.

SOURCE Medicago Inc.

Medicago Inc.       
Andy Sheldon
President and CEO
(418) 658-9393

Medicago Inc.
Christina Cameron
Investor Relations
(418) 658-9393 ext.156
cameronc@medicago.com

Medicago Shareholders Approve Arrangement with Mitsubishi Tanabe Pharma Corporation

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QUEBEC CITY, Aug. 29, 2013 /CNW/ - Medicago Inc. (TSX: MDG; OTCQX: MDCGF) ("Medicago" or the "Company"), a biopharmaceutical company focused on developing highly effective and competitive vaccines based on proprietary manufacturing technologies and Virus-Like Particles (VLPs), during today's special meeting of shareholders of Medicago (the "Meeting"), is pleased to annouce that its shareholders have approved the resolution authorizing the previously announced plan of arrangement (the "Arrangement") involving the Company, Mitsubishi Tanabe Pharma Corporation (the "MTPC") and 9284-9686 Québec Inc. (the "Purchaser"), a wholly-owned subsidiary of MTPC.

The Arrangement resolution required the approval of 66 2/3% of the votes cast by shareholders of Medicago and of the simple majority of the votes cast by shareholders of Medicago excluding MTPC, Philip Morris Investments B.V. ("PMI") and any of their respective affiliates in each case present in person or represented by proxy at the Meeting. Shareholders of Medicago representing 83.6% of all issued and outstanding shares of Medicago were present or represented by proxy at the Meeting.

The Arrangement resolution was approved by 97.5% of the shareholders of Medicago and by 94.8% of the shareholders of Medicago, excluding MTPC, PMI, and their respective affiliates, present in person or represented by proxy at the Meeting.

In addition, a resolution related to the Interim Funding Arrangement was approved by 98.5% of the shareholders of Medicago and by 98.4% of the shareholders of Medicago excluding MTPC and its affiliates. For additional details on the Interim Funding Arrangement, please refer to the company's Information Circular dated July 31, 2013 (the "Circular") available on SEDAR at www.sedar.com.

Under the Arrangement, the Purchaser will acquire all of the issued and outstanding common shares of the Company not held by MTPC and PMI for a cash consideration of $1.16 per common share, all as more particularly described in the Circular. In addition, holders of warrants and options will each receive a cash payment equal to the difference between $1.16 and the exercise price of each warrant or option. Completion of the Arrangement remains subject to, among other things, the final approval of the Superior Court of Quebec. The hearing for the final court order to approve the Arrangement is scheduled to take place on September 4, 2013 in Quebec City. Assuming that all regulatory approvals are obtained, Medicago currently anticipates the closing of the Arrangement to occur around mid-September 2013.

Further details regarding the Arrangement are set out in the press release dated July 12, 2013 and in the Circular, copies of which are available under the corporate profile of the Company on SEDAR at www.sedar.com and on the Company's website at www.medicago.com.

About Medicago
Medicago is a clinical-stage biopharmaceutical company developing novel vaccines and therapeutic proteins to address a broad range of infectious diseases worldwide. Medicago is committed to providing highly effective and competitive vaccines and therapeutic proteins based on its proprietary VLP and manufacturing technologies. Medicago is a worldwide leader in the development of VLP vaccines using a transient expression system which produces recombinant vaccine antigens in plants. This technology has potential to offer more potent vaccines with speed and cost advantages over competitive technologies, enabling the development of a vaccine for testing in approximately one month after the identification and reception of genetic sequences from a pandemic strain. This production time frame has the potential to allow vaccination of the population before the first wave of a pandemic, and supply large volumes of vaccine antigens to the world market. Medicago also intends to expand development into other areas such as biosimilars and biodefense products where the benefits of our technologies can make a significant difference. Additional information about Medicago is available at www.medicago.com.

About Mitsubishi Tanabe Pharma
Mitsubishi Tanabe Pharma is a research-driven pharmaceutical company based in Japan, specializing in research, development and marketing of globally competitive pharmaceutical products focused on the field of autoimmune disease, diabetes and kidney disease, and CNS disease.Mitsubishi Tanabe Pharma contributes to the healthier lives of people around the world through the creation of pharmaceuticals that respond to unmet medical needs. Additional information about MTPC is available at http://www.mt-pharma.co.jp/e.

Forward Looking Statements
This news release includes certain forward-looking statements or forward-looking information for the purposes of applicable securities laws and such statements and information are based upon current expectations, which involve risks and uncertainties associated with Medicago's business and the environment in which the business operates. Any statements contained herein that are not statements of historical facts may be deemed to be forward-looking, including those identified by the expressions "anticipate", "believe", "plan", "estimate", "expect", "intend", and similar expressions to the extent they relate to Medicago or its management. The forward-looking statements are not historical facts, but reflect Medicago's current expectations regarding future results or events. These forward-looking statements are subject to a number of risks and uncertainties that could cause actual results or events to differ materially from current expectations, including the matters discussed under "Risk Factors and Uncertainties" in Medicago's Annual Information Form filed on March 28, 2013, with the regulatory authorities. Medicago assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those reflected in the forward-looking statements.


SOURCE Medicago Inc.

Medicago Inc.
Andy Sheldon
President and CEO
(418) 658-9393

Medicago Inc. 
Christina Cameron
Investor Relations
(418) 658-9393 ext.156
cameronc@medicago.com

Medicago Announces Receipt of Final Court Order and Regulatory Approvals for Arrangement with Mitsubishi Tanabe Pharma

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QUEBEC CITY, Sept. 12, 2013 /CNW/ - Medicago Inc. (TSX: MDG; OTCQX: MDCGF) ("Medicago" or the "Company"), a biopharmaceutical company focused on developing highly effective and competitive vaccines based on proprietary manufacturing technologies and Virus-Like Particles (VLPs), is pleased to announce that the Superior Court of Quebec has granted its final order approving the previously announced plan of arrangement (the "Arrangement") involving the Company, Mitsubishi Tanabe Pharma Corporation ("MTPC") and 9284-9686 Québec Inc., a wholly-owned subsidiary of MTPC (the "Purchaser").

Under the Arrangement, the Purchaser will acquire all of the issued and outstanding common shares ("Common Shares") of the Company, other than the Common Shares currently held by MTPC and by Philip Morris Investments B.V. ("PMI") an affiliate of Philip Morris International Inc. for cash consideration of $1.16 per Common Share. In addition, holders of warrants and options will each receive a cash payment equal to the difference between $1.16 and the exercise price of such warrants or options.

In addition, all regulatory approvals required for the Arrangement have now been obtained. Assuming all other closing conditions are satisfied or waived, it is anticipated that the Arrangement will become effective on September 18, 2013 (the "Effective Date"). The Common Shares are expected to be delisted from the Toronto Stock Exchange promptly following the Effective Date. Following completion of the Arrangement, the Company will also apply to cease to be a reporting issuer under applicable Canadian securities laws.

Further details regarding the Arrangement are set out in the press release dated July 12, 2013 and in the Company's Information Circular ("Circular") dated July 31, 2013, which are available under the corporate profile of the Company on SEDAR at www.sedar.com and on the Company's website at www.medicago.com.

About Medicago
Medicago is a clinical-stage biopharmaceutical company developing novel vaccines and therapeutic proteins to address a broad range of infectious diseases worldwide. Medicago is committed to providing highly effective and competitive vaccines and therapeutic proteins based on its proprietary VLP and manufacturing technologies. Medicago is a worldwide leader in the development of VLP vaccines using a transient expression system which produces recombinant vaccine antigens in plants. This technology has potential to offer more potent vaccines with speed and cost advantages over competitive technologies, enabling the development of a vaccine for testing in approximately one month after the identification and reception of genetic sequences from a pandemic strain. This production time frame has the potential to allow vaccination of the population before the first wave of a pandemic, and supply large volumes of vaccine antigens to the world market. Medicago also intends to expand development into other areas such as biosimilars and biodefense products where the benefits of our technologies can make a significant difference. Additional information about Medicago is available at www.medicago.com.

About Mitsubishi Tanabe Pharma
Mitsubishi Tanabe Pharma is a research-driven pharmaceutical company based in Japan, specializing in research, development and marketing of globally competitive pharmaceutical products focused on the field of autoimmune disease, diabetes and kidney disease, and CNS disease.Mitsubishi Tanabe Pharma contributes to the healthier lives of people around the world through the creation of pharmaceuticals that respond to unmet medical needs. Additional information about MTPC is available at http://www.mt-pharma.co.jp/e.

Forward Looking Statements
This news release includes certain forward-looking statements or forward-looking information for the purposes of applicable securities laws and such statements and information are based upon current expectations, which involve risks and uncertainties associated with Medicago's business and the environment in which the business operates. Any statements contained herein that are not statements of historical facts may be deemed to be forward-looking, including those identified by the expressions "anticipate", "believe", "plan", "estimate", "expect", "intend", and similar expressions to the extent they relate to Medicago or its management. The forward-looking statements are not historical facts, but reflect Medicago's current expectations regarding future results or events. These forward-looking statements are subject to a number of risks and uncertainties that could cause actual results or events to differ materially from current expectations, including the matters discussed under "Risk Factors and Uncertainties" in Medicago's Annual Information Form filed on March 28, 2013, with the regulatory authorities. Medicago assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those reflected in the forward-looking statements.


SOURCE Medicago Inc.

Medicago Inc. 
Andy Sheldon
President and CEO
(418) 658-9393

Medicago Inc.
Christina Cameron
Investor Relations
(418) 658-9393 ext.156
cameronc@medicago.com

Mitsubishi Tanabe Pharma Completes Acquisiton of Medicago

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OSAKA, Japan and QUEBEC CITY, Canada, Sept. 18, 2013 /CNW/ - Mitsubishi Tanabe Pharma Corporation (TSE: 4508) ("Mitsubishi Tanabe Pharma" or "MTPC") and Medicago Inc. (TSX: MDG) announced today the completion of the previously announced acquisition of Medicago Inc. by MTPC.

On September 18, 2013, 9284-9686 Québec Inc.,a subsidiary of MTPC, acquired all of the outstanding common shares of Medicago, other than the common shares currently held by MTPC and Philip Morris Investments B.V. ("PMI") an affiliate of Philip Morris International Inc., pursuant to the terms of an arrangement agreement made as of July 12, 2013. As a result, Medicago has become jointly owned by MTPC (60%) and PMI (40%). Shareholders of Medicago, as of the effective date of the arrangement, will be entitled to receive $1.16 per common share in cash, and holders of warrants and stock options will be entitled to receive a cash payment equal to the difference between $1.16 and the exercise price of any warrant or stock option they hold.

The common shares of Medicago will be delisted from trading on theToronto Stock Exchange, at the end of trading on September 19, 2013.

"We are very pleased with the completion of this transaction and welcome Medicago to our group.  We look forward to working with Medicago's management and employees as well as all the stakeholders to develop highly effective and competitive vaccines based on Medicago's proprietary technologies to contribute to the healthier lives of people around the world," said Dr. Michihiro Tsuchiya, President and Chief Executive Officer of MTPC.

"I would like to sincerely thank our employees, investors , partners and board members for their important contribution leading to Medicago's success, said Andy Sheldon, President and Chief Executive Officer of Medicago. I would also like to thank our corporate partners MTPC and PMI for their confidence in Medicago. We look forward to working closely with them to ensure our innovative, effective and cost efficient technology and products are brought to market".

The acquisition of Medicago will be entirely satisfied with cash and sufficient funds have been deposited with Computershare Investor Services Inc. to enable it to make payments to Medicago shareholders, warrantholders and optionholders pursuant to the terms of the arrangement agreement. Letters of Transmittal have been mailed to registered shareholders of Medicago and are also available on SEDAR at www.sedar.com. The Letters of Transmittal explain how registered Medicago shareholders can deposit and obtain payment for their shares. Registered Medicago shareholders must return duly completed Letters of Transmittal to Computershare Investor Services Inc. in order to receive the consideration to which they are entitled for their shares. Non-registered shareholders should carefully follow the instructions from the broker or other financial intermediary that holds shares on their behalf.

About Medicago
Medicago is a clinical-stage biopharmaceutical company developing novel vaccines and therapeutic proteins to address a broad range of infectious diseases worldwide. Medicago is committed to providing highly effective and competitive vaccines and therapeutic proteins based on its proprietary VLP and manufacturing technologies. Medicago is a worldwide leader in the development of VLP vaccines using a transient expression system which produces recombinant vaccine antigens in plants. This technology has potential to offer more potent vaccines with speed and cost advantages over competitive technologies, enabling the development of a vaccine for testing in approximately one month after the identification and reception of genetic sequences from a pandemic strain. This production time frame has the potential to allow vaccination of the population before the first wave of a pandemic, and supply large volumes of vaccine antigens to the world market. Medicago also intends to expand development into other areas such as biosimilars and biodefense products where the benefits of our technologies can make a significant difference. Additional information about Medicago is available at www.medicago.com.

About Mitsubishi Tanabe Pharma
Mitsubishi Tanabe Pharma is a research-driven pharmaceutical company based in Japan, specializing in research, development and marketing of globally competitive pharmaceutical products focused on the field of autoimmune disease, diabetes and kidney disease, and CNS disease.Mitsubishi Tanabe Pharma contributes to the healthier lives of people around the world through the creation of pharmaceuticals that respond to unmet medical needs. Additional information about MTPC is available at http://www.mt-pharma.co.jp/e.

Forward Looking Statements
This news release includes certain forward-looking statements or forward-looking information for the purposes of applicable securities laws and such statements and information are based upon current expectations, which involve risks and uncertainties associated with Medicago's business and the environment in which the business operates. Any statements contained herein that are not statements of historical facts may be deemed to be forward-looking, including those identified by the expressions "anticipate", "believe", "plan", "estimate", "expect", "intend", and similar expressions to the extent they relate to Medicago or its management. The forward-looking statements are not historical facts, but reflect Medicago's current expectations regarding future results or events. These forward-looking statements are subject to a number of risks and uncertainties that could cause actual results or events to differ materially from current expectations, including the matters discussed under "Risk Factors and Uncertainties" in Medicago's Annual Information Form filed on March 28, 2013, with the regulatory authorities. Medicago assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those reflected in the forward-looking statements.

SOURCE Medicago Inc.

Medicago Inc.       
Andy Sheldon
President and CEO
(418) 658-9393
 
Medicago Inc.
Christina Cameron
Investor Relations
cameronc@medicago.com
(418) 658-9393 ext.156

For inquiries regarding Mitsubishi Tanabe Pharma Corporation:

Mitsubishi Tanabe Pharma Corporation
Yoshihisa Sasou
General Manager
Corporate Communications Department
81-6-6205-5110


Medicago awarded a contract by the U.S. Department of Health and Human Services to explore alternate production methods for Ebola antibodies

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QUEBEC CITY, Feb. 24, 2015 /CNW Telbec/ - Medicago, a leading company in the development and production of plant-based vaccines and therapeutics, announced today that it has received a task order from the Biomedical Advanced Research and Development Authority (BARDA) at the U.S. Department of Health and Human Services (HHS) for three anti-Ebola virus monoclonal antibodies (mAbs) with expected performance comparable to that of ZMapp™, from Mapp Biopharmaceutical.

Medicago will manufacture the antibodies in its Quebec City, Canada facility, for a study in non-human primates (NHP). Two of these antibodies were discovered by the Public Health Agency of Canada. This order is the result of a Task Order Request (TOR) that was solicited by BARDA on December 22, 2014. It is part of the Indefinite Delivery/Indefinite Quantity (ID/IQ) contract between Medicago and the Defense Advanced Research Projects Agency (DARPA).

Joining the global efforts against Ebola

Medicago is pleased to join the international efforts against the Ebola virus. Medicago intends to demonstrate the comparable performance of its anti-Ebola antibodies to ZMappTM.

"Medicago's production platform has demonstrated its important potential for responding to international emergencies and pandemics when it produced candidate vaccines for H1N1 in 2009 and H7N9 in 2013," said Andy Sheldon, Medicago's CEO. "As governments around the world continue to face health threats like pandemic strains of influenza and Ebola viruses, we believe that Medicago can make a major contribution to rapid response, surge capacity and stockpiles across the globe."

Preliminary results have shown that Medicago's technology can rapidly produce anti-Ebola antibodies with high yields, thereby potentially boosting production volumes and worldwide supply.

In accordance with U.S. Federal Acquisition Regulations (FAR 16.505 (b)(1)), this TOR allowed all four awardees of the DARPA ID/IQ contracts to compete. Medicago's ID/IQ contract was awarded in December 2012.

About Medicago

Medicago is a clinical-stage biopharmaceutical company developing novel vaccines and therapeutic proteins to address a broad range of infectious diseases worldwide. The company is committed to providing highly effective and competitive vaccines and therapeutic proteins based on its proprietary Virus-Like Particles (VLPs) and manufacturing technologies.

This technology has the potential to offer vaccines and therapeutics with speed and cost advantages over competitive technologies, enabling the development of products for testing within approximately one month after the identification and reception of genetic sequences. This production time frame has the potential to rapidly vaccinate or treat populations and supply large volumes of product to the global market.  www.medicago.com

About BARDA

The Biomedical Advanced Research and Development Authority (BARDA), within the Office Of the Assistant Secretary for Preparedness and Response (ASPR) in the U.S. Department Of Health and Human Services, provides an integrated, systematic approach to the development and purchase of the necessary vaccines, drugs, therapies, and diagnostic tools for public health medical emergencies. www.medicalcountermeasures.gov

SOURCE Medicago Inc.

TACT Intelligence-conseil, Michelle O'Brodovich, Phone: 418-529-3223, ext. 32, Cell: 418-933-3476, mobrodovich@tactconseil.ca; For inquiries regarding BARDA: ASPR Public Affairs, Director, Gretchen Michael, Phone: 202-205-8114, Gretchen.Michael@hhs.gov

Medicago engaged by the Canadian Government to develop Ebola monoclonal antibodies

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QUEBEC, Oct. 29, 2015 /CNW Telbec/ - Medicago, a leading Canadian company in the development and production of plant-based therapeutics and vaccines, has been awarded a contract by the Public Health Agency of Canada (PHAC) to develop two antibodies to fight the Sudan strain of the Ebola virus. Medicago will produce these antibodies at its facility in Quebec City.

In producing this technology, Medicago will demonstrate a Canadian capability to manufacture monoclonal antibodies as part of emergency preparedness and response efforts. The Canadian government and Medicago are now working together on antibodies for the Sudan strain lineage, building on existing work directed at the Zaire strain which is responsible for the ongoing outbreak in West Africa. According to the World Health Organization (WHO), the Ebola Sudan strain has previously been associated with large-scale outbreaks in Africa. The availability of an effective antibody would allow for an early intervention in case of a new outbreak involving the Sudan strain. 

"Medicago will be using its technology and manufacturing system to collaborate with the Canadian government to provide a solution for the possible re-emergence of this devastating disease," said Andy Sheldon, CEO of Medicago. "We are also proud to work on a Canadian solution that can be employed as a response to other biological threats that may impact national and international security in the future."

Using plants to fight Ebola, seasonal and pandemic influenza, and other health threats
Medicago's innovative technology uses plants as miniature factories that can quickly produce large quantities of vaccines or antibodies. This technology demonstrated its potential for responding to global pandemics when it produced candidate vaccines for H1N1 in 2009 and H7N9 in 2013 in just 19 days, compared to the several months required to produce vaccines using eggs.

The company, which recently announced an important expansion of its Quebec City facilities in May 2015, can rapidly produce anti-Ebola antibodies with high yields. Prior to this award, Medicago successfully completed the recent contract signed with the U.S. government to explore an alternate production method for Ebola antibodies against the Zaire strain. As governments around the world continue to face health threats such as pandemic strains of influenza and Ebola viruses Medicago has the potential to respond to international emergencies and can make a major contribution to rapid response, surge capacity and stockpiles across the globe.

About Medicago
Medicago is a clinical-stage biopharmaceutical company developing novel vaccines and therapeutic proteins to address a broad range of infectious diseases worldwide. The company is committed to providing highly effective and competitive vaccines and therapeutic proteins based on its proprietary Virus-Like Particles (VLPs) and manufacturing technologies.

This technology has the potential to offer vaccines and therapeutics with speed and cost advantages over competitive technologies, enabling the development of products for testing within approximately one month after the identification and reception of genetic sequences. This production time frame has the potential to rapidly vaccinate or treat populations and supply large volumes of products to the world market. 

About the Public Health Agency of Canada's Research
Canada remains actively engaged and committed to supporting the global effort to combat Ebola virus disease. The two monoclonal antibodies (mAbs) to be produced with this contract were discovered by scientists at the Public Health Agency of Canada's (The Agency) National Microbiology Laboratory in Winnipeg, Man.  Researchers at the National Microbiology Laboratory also worked to develop Canada's VSV-EBOV Ebola vaccine — one of the leading vaccine candidates currently in clinical trials in Canada, the United States, Europe and West Africa.

 

SOURCE Medicago Inc.

Medicago Inc. media contact: Michelle O'Brodovich, Phone: 418-529-3223, ext. 32, Cell: 418-933-3476, mobrodovich@tactconseil.ca; For inquiries regarding the Public Health Agency of Canada: Media Relations, Public Health Agency of Canada, 613-957-2983




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